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Earlier in this chapter we pointed out that lipid bilayers are very much not permeable to ions. In almost all cases, transport of ions across the membrane requires the existence of an ion channel, which is a transport protein as we described above with a hollow channel lined with hydrophilic residues. (One exception is vesicle transport discussed later in this chapter.) In some cases the native state of the membrane transport protein involves two or more native conformations. In at least one of these conformations the transport channel is blocked, preventing the movement of ions into the channel through either steric or hydrophobic forces. Such a channel is said to be gated because the conformation of the protein acts as a gate that can open and close. Depending on the particular transport protein and its specific purpose, various factors can act to trigger the conformational change to open or close the gate. For example, binding of a protein or other molecule to a specific receptor on the surface of the membrane may trigger the gate to open or close. Or the presence of a certain voltage difference across the membrane may trigger the conformational change that opens or closes the ion channel. This latter situation is referred to as a voltage gated ion channel. Voltage gated ion channels are common in nerve cells (neurons) and other excitable tissue (muscle cells). Typically there is a very specific voltage at which the gated ion channels of a cell open in a highly cooperative manner, so that once one channel is open, the other channels along the length of the neuron open rapidly in succession, creating an impulse that travels down the length of the neuron.

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the same way as with DS2, this network overhead is used to maintain frame synchronization but also is used for stuffing indicators, parity checks, and subframe indicators.

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clone. Select the master control object and change one or more of its properties. Notice the master and the properties of both clones also change. Once your first clone has been created, a hierarchy is created. You can create additional clones from the master control object, but you can t create clones from clones that would be silly and confusing.

Oracle Database Server #1

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4 Recognize and Activate Your Inner Voice of Wisdom and Courage 53 CHAPTER 5 Cultivating Interests Before Callings 71 CHAPTER 6 Pace Yourself Life Isn t an All-or-Nothing Proposition 107

The advantage of PN Agent (and the ICA Web client) over the full Program Neighborhood client is that it is configured centrally via the Program Neighborhood Agent Web Interface site (refer to Figure 15-2) which changes a config.xml file on the Web Interface server rather than configuration files located on the local devices. Users logon methods, shortcuts, and access to the user interface are determined by the options set using the Program Neighborhood Agent site. Users ability to determine their own logon method, audio settings, shortcut placement, and display settings can all be allowed or denied, depending on the organization s needs.

U n s a f e C o d e , P o i n t e r s , N u l l a b l e Ty p e s , D y n a m i c Ty p e s , a n d M i s c e l l a n e o u s To p i c s

Because a Blu-ray Disc can contain any type of computer data and software, the content possibilities are practically endless. Video and audio, of course, are simply another form of digital data but, in general, when people talk about data on optical discs they are referring to computer data such as software applications, text files, and so on. Often the term BD-ROM is used to refer to data-only discs, even when they are recordable, which is a misnomer. Although CD-ROMs and recordable CDs are still widely used for PC applications and data storage, DVD-ROM and recordable DVDs have become more popular. DVD drives have become even more popular, as they can read and write CDs. Blu-ray will displace DVD

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1. Preliminary diagnostic design The steps are: Preparing plans indicating type, size, and location (TS & L) Preparing plans indicating geometry, alignment, pro le, span length, and beam spacing Preparing a report on accessibility to the site, estimates of cost, and material availability. 2. Final Diagnostic Design The steps are: Preparing plans, speci cations, and estimates (PS & E) Adjusting maximum truck load: After rehabilitation, the number of fatigue cycles and fatigue stress level are expected to be lower since the remaining useful life of the substructure is reduced to less than the original estimated life of 75 years. A fatigue evaluation study needs to be carried out for the remaining fatigue life for the level of live loads (Table 1.5). Posting the bridge for a lower live load.

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