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W. Bay St. (P.O. Box N-8306), Cable Beach, Nassau, The Bahamas. & 800/222-7466 in the U.S. or 242/327-6200. Fax 242/327-6818. www.wyndham.com/hotels/NASBS/ main.wnt. 857 units. Winter $179 $250 double, $250 $500 suite; off-season $119 $139 double, $220 $230 suite. AE, DC, DISC, MC, V. Free self-parking; valet parking $5. Bus: 10. Amenities: 6 restaurants; 3 bars; pool; golf course; 10 tennis courts; health club; 24-hr. room service; babysitting; laundry service. In room: A/C, TV, minibar, hair dryer, safe.

example, has found that patients with CFS have parents with increased prevalence of cancer and autoimmune disorders when compared to control patients families. Recent twin studies of complex genetic and environmental relationships between psychological distress, fatigue, and immune system functioning suggest that these models need to acknowledge the increasing importance of the individual s genotype (Hickie, Bennett, Lloyd, Heath, & Martin, 1999). One strength of a biopsychosocial understanding of CFS is that it may serve as a means of bridging the theoretical gap between mind versus body explanations of these illnesses. Similarly, a psychoneuroimmunological model (Jason et al., 1995) can provide another comprehensive heuristic framework for understanding this complex illness. Psychoneuroimmunology presents an alternative to current research-induced dichotomous conceptualizations as solely diseases of the body or the mind. A psychoneuroimmunological model suggests that an ongoing connection exists between nervous, endocrine, and immune systems within the body. Consequently, conditions of stress, depression, anxiety, loss of control, learned helplessness, loneliness, bereavement, or highly inhibited power motivation may interfere with adequate immune functioning. Psychological and environmental factors may serve to in uence immunosuppression, including dysphoric responses (e.g., depressive affect, unhappiness, anxiety), immunosuppressive behaviors (e.g., dietary patterns, sleep habits, licit and illicit drug use), adverse life experiences (e.g., ongoing strains in interpersonal relationships), and preexisting vulnerabilities (e.g., the absence of interpersonal resources and coping patterns to forestall the impact of negative life experiences). In summary, psychoneuroimmunology provides a transactional model, which accounts for complex interactions between multiple biological and psychological factors that in uence both the onset of these syndromes and pathways to further illness or recovery.

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Lazarus, HM, Haynesworth, SE, Gerson, SL, Caplan, AI (1997): Human bone marrowderived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections J Hematol 6: 447 455 Lee, JY, Qu-Petersen, Z, Cao, B, Kimura, S, Jankowski, R, Cummins, J, Usas, A, Gates, C, Robbins, P, Wernig, A, Huard, J (2000): Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing J Cell Biol 150: 1085 1099 Lennon, DP, Haynesworth, SE, Bruder, SP, Jaiswal, N, Caplan, AI (1996): Human and animal mesenchymal progenitors from bone marrow: identi cation of serum for optimal selection and proliferation In vitro Cell Dev Biol Anim 32: 602 611 Lennon, DP, Haynesworth, SE, Arm, DM, Baber, M.

A, Caplan, AI (2000): Dilution of human mesenchymal stem cells with dermal broblasts and the effects on in vitro and in vivo osteochondrogenesis Dev Dyn 219: 50 62 Lennon, DP, Edmison, JM, Caplan, AI (2001): Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis J Cell Physiol 187: 345 355 Majumdar, MK, Thiede, MA, Mosca, JD, Moorman, M, Gerson, SL (1998): Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells J Cell Physiol 176: 57 66 Mann, LM, Lennon, DP, Caplan, AI (1996): Cultured rat pulp cells have the potential to form bone, cartilage, and dentin in vivo In Davidovitch, Z, Norton, LA, eds.

, Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Harvard Society for the Advancement of Orthodontics, Boston, pp 7 16 Minguell, JJ, Erices, A, Conget, P (2001): Mesenchymal stem cells Exp Biol Med 226: 507 520 Morrison, SJ, Shah, NM, Anderson, DJ (1997): Regulatory mechanisms in stem cell biology Cell 88: 287 296 Mosca, JD, Majumdar, MK, Hardy, WB, Pittenger, MF, Thiede, MA (1997): Initial characterization of the phenotype of the human mesenchymal stem cells and their interaction with cells of the hematopoietic lineage Blood 88: 186a Nakahara, H, Goldberg, VM, Caplan, AI (1991): Culture-expanded human periosteal-derived cells exhibit osteochondral potential in vivo J Orthop Res 9: 465 476 Ohgushi, H, Goldberg, VM, Caplan, AI (1989): Heterotopic osteogenesis in porous ceramics induced by marrow cells.

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