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available in the United States for medical use Botox Cosmetic (Allergan Inc, Irvine, CA) and Dysport (Ipsen Products, Maidenhead, Berkshire, UK) are both formed from serotype A, which functions by cleaving the SNAP-25 protein, a component of the SNARE (Soluble N-ethylmaleamide-sensitive factor Attachment protein Receptor) complex (Box 22-2) The presence of an intact SNARE complex, composed of synaptobrevin, SNAP-25, and syntaxin, is necessary for vesicles containing ACh to fuse with the cell membrane and to release ACh into the neuromuscular junction (Fig 22-1) BTX-B, now available in the United States as Myobloc (known as Neurobloc in Europe), cleaves synaptobrevin, thus preventing the release of ACh

Multiple database users trying to change the same rows need to wait for each other, so writers may block other writers. Each attempt to change a row tries to acquire the corresponding row-level lock first. If the lock cannot be acquired, you must wait until the pending change is committed or rolled back. All row-level locks are released upon a COMMIT (explicit or implicit) or ROLLBACK. This means that the Oracle DBMS tries to minimize locking overhead and tries to maximize throughput and concurrency.

CHAPTER 3:

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In a database environment, read consistency is an important concept. Read consistency is a first requirement to guarantee correct query results. Regardless of how long it runs and regardless what else happens simultaneously in the database, the Oracle DBMS must make sure that each SQL query maintains access to a consistent snapshot of the data at the point in time when the query started. It needs this snapshot because a query should never see any uncommitted changes. Moreover, a query should not see changes that were committed after the query started. This means that the Oracle DBMS must be able to reconstruct previous versions of the data in order to process queries. We will not go into technical details here, but the Oracle DBMS accomplishes this (without using locking) by using information stored in undo segments. Believe it or not, read consistency is even important in a single-user environment. Suppose that upper management has decided to grant a salary raise of 50% to all employees who currently earn less than the average salary of their department. You might want your salary to be checked last by the UPDATE statement, hoping that earlier salary raises have

Acetylcholine (ACh) is the neurotransmitter associated with induction of musFIGURE 22-1 Botulinum toxins inhibit the release of acetylcholine into the neuromuscular junction

influenced your department s average salary in such a way that you became entitled to a raise, too. In an Oracle environment, this hope is in vain, because the read consistency mechanism will ensure that the subquery in the UPDATE statement (to derive the average salary of your department) returns the same result, regardless of how often the subquery is reexecuted for the same department, within the scope of that single UPDATE command. By default, read consistency is implemented at the statement level. In case you need read consistency at the transaction level for example, for a report that consists of multiple queries you must do something to override this default behavior to guarantee consistent report results. In such a situation, you could decide to manually lock all tables with the LOCK TABLE command. However, locking data prevents concurrent transactions from changing that data, resulting in wait situations and reducing throughput. Therefore, locking the data manually is not a recommended approach. There is a better solution in this situation, without the disadvantages of using locking: the SQL command SET TRANSACTION. This command allows you to specify the desired transaction isolation level (in compliance with the ANSI/ISO SQL standard). See Figure 6-7 for the (partial) syntax of this command.

FIGURE 3-12

Figure 6-7. SET TRANSACTION command syntax diagram The components of the SET TRANSACTION command work as follows: READ WRITE is the Oracle default, implementing statement-level read consistency. READ ONLY implements transaction-level read consistency. ISOLATION LEVEL READ COMMITTED is the Oracle default behavior. ISOLATION LEVEL SERIALIZABLE implies the failure of DML statements that attempt to update rows that already had pending changes when the serializable transaction started. In the situation of the report consisting of multiple queries, issuing the SET TRANSACTION READ ONLY command at the beginning of the transaction would be the right choice. But note that because the Oracle DBMS does not use any locking or other obstructive techniques when you do this, you incur the risk that, at a certain point in time, the Oracle DBMS will not be able to reconstruct the desired original data anymore, especially if your read-only transaction is running a long time. You get the following error message in such situations:

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