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Premenopausal women, in comparison to men, are felt to be protected against cardiovascular disease by estrogens It is then paradoxical that in cross-sectional studies of men, elevated levels of estrogens [115] and relatively low levels of T [116,122,123] appear to be associated with coronary disease and myocardial infarction These studies suggest the intriguing possibility that, in spite of the prior assumption of overall negative effects of androgens on lipid pro les, a lower-than-normal androgen level in aging men is associated with an increase of atherosclerotic disease In a study of geriatric male patients who had suffered a myocardial infarction, it was found that these patients had low T levels [116] In addition four trials have found that pharmacologic doses of T relax coronary arteries when injected intraluminally, and modest but consistent improvement of exercise-induced angina and electrocardiographic ischemia have been observed following short-term T administration in at least ve RCTs [123 127] These results are encouraging but they await longer-term investigations On the other hand no bene cial effect could be demonstrated on peripheral arterial disease, and possible effects on cerebrovascular disease have not been evaluated [124,126] The apparently negative effect of androgens in old studies may have been due, in part, to the supraphysiologic levels of T achieved when injectable T esters were used The explanation may also lie in the fact that T also exerts both bene cial and adverse effects on the vascular wall, and that a complex of risk factors for cardiovascular disease termed syndrome X or the metabolic syndrome (comprising hypertension, insulin resistance, hypertriglyceridemia, and visceral obesity) is associated with low T levels [83,84,115,128]

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Banks Generally, a bank recognizes gain or loss on foreclosure of property securing a loan, but is not permitted to deduct any further decrease in or impairment of value Any decrease in value occurring after foreclosure is recognized when the property is disposed of by the institution If real property acquired through foreclosure is operated in a trade or business after foreclosure (eg, as rental property), the institution may deduct depreciation (and other operating expenses) computed in accordance with general tax depreciation provisions Thrifts Effective for taxable years beginning after December 31, 1995, thrift institutions are subject to the same rules as banks Under prior law, a special rule treated the acquisition of property by a thrift as a nontaxable event, with no gain or loss recognized at time of foreclosure and no depreciation allowed on the property A subsequent write-down charge to the bad debt reserve was allowed if the fair market value of the property was less than the tax basis of the loan Upon nal disposition, the gain or loss was credited or charged to the bad debt reserve

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Premenopausal women suffer signi cantly less from cardiovascular disease than men, and traditionally it has been thought that the relationship between sex steroids and cardiovascular disease is predominantly determined by the relatively bene cial effects of estrogens, and by the relatively detrimental effects of androgens on lipid pro les [101] Nevertheless, the vast majority of cross-sectional studies in men are not in agreement with this assumption; they show a positive correlation between FT levels and HDL cholesterol [111 113], and a negative correlation, with brinogen, plasminogen activator inhibitor-1 [105], and insulin levels as well as with coronary heart disease [115,116], but not with cardiovascular mortality [117 119] Recent research shows the effects of sex steroids on biologic systems other than lipids Fat distribution, endocrine/paracrine factors produced by the vascular wall (such as endothelins, nitric oxide), blood platelets and coagulation, must also be considered in the analysis of the relationship between sex steroids and cardiovascular disease [120,121]

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