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As effective as plasma exchange is, IVIG (04 g/kg per day for 5 consecutive days) is both easier to administer and probably safer because there is no need for large intravenous access The results of the original trial conducted by van der Meche and col leagues have been corroborated in an international study led by Hughes, in which we participated The latter study compared plasma exchange to IVIG and also evaluated their serial use There was a tenuous trend toward a better outcome in patients who received plasma exchange, and results were perhaps slightly better in a group who were treated with plasma exchange followed immediately by 5 days of immune globulin infusions; in both instances, however, the differences failed to attain statistical signi cance and the three modes of treatment were said to be equivalent.

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Renal failure, proteinuria, and aseptic meningitis manifested most often by severe headache are rare complications of IVIG The only serious reactions we have encountered were in a very few patients who congenitally lacked IgA and in whom pooled gamma globulin caused anaphylaxis We have also encountered a few cases of marked in ammatory local venous thrombosis in the region of the infusion site After the use of either plasma exchange or IVIG, 5 to 10 percent of patients who initially improve will have a relapse that becomes apparent several days or up to 3 weeks after completion of treatment If there was a good response to the initial therapy, the same treatment may be repeated or the alternative treatment may be tried; either can be successful A few such patients relapse repeatedly and have a course indicative of chronic in ammatory demyelinating polyneuropathy (see further on).

In a few such patients under our care the disease stabilized after several months in response to the administration of corticosteroids, with very gradual tapering of the dose over several months, or in combination with repeated courses of IVIG or plasma exchanges It should be pointed out that the clinical improvement that follows the administration of IVIG or PE usually cannot be readily discerned in an individual patient, ie, it is apparent only by comparing treated and untreated large groups For this reason it is not possible to judge that a patient who fails to improve or who worsens through the period of treatment has indeed derived no bene t from therapy The question nevertheless arises regarding further plasma exchanges or continued infusion of immune globulin in cases of continued worsening or lack of improvement.

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Further complicating the matter are the limited expectations for early improvement in cases of axonal GBS Our advice has been to repeat either of the two treatments if a patient is clearly declining, particularly if there is evidence of mainly demyelinating disease on the EMG, and if.

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