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The first formation of a carbon carbon bond occurs between malonyl and acetyl units bound to fatty acid synthase After reduction, dehydration, and further reduction, the acyl enzyme is condensed with more malonyl-CoA and the cycle is repeated until the acyl chain grows to C16 When the growing fatty acid reaches a chain length of 16 carbons, the acyl group is hydrolyzed to give the free fatty acid

FIGURE 5-7

From TCA and mitochondria through citrate to C16 fatty acid Through C16-acyl-CoA to elongation and desaturation pathways Through C16-acyl-CoA to triglycerides

Primary signals: Insulin turns on Glucagon turns off Epinephrine turns off Phosphorylation turns off Citrate activates (acetyl-CoA carboxylase)

Oracle Enterprise Manager can monitor the Exadata Storage Servers through the System Monitoring Plug-in for Exadata and the Enterprise Manager Ops Center connector These topics are discussed next

Secondary signals:

The major control point for fatty acid synthesis is acetyl-CoA carboxylase The enzyme is inactivated by phosphorylation and activated by high concentrations of citrate

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Now look at Figure 68 for the pro t and loss model on the bull call spread You can see that this model has both a limited risk and a limited pro t potential The total maximum pro t potential is the $1,550 we calculated previously, and the maximum risk is the net option premium spent on the position Also notice that the pro t and loss occurs slowly at intermediate time frames represented by the dashed and dotted lines This slow growth in premium is a result of the decreased delta of the spread This is a disadvantage of the bull call spread With the long 420 call having a delta of 584 percent and the short 470 call having a delta of 388 percent, the net long delta movement against the underlying futures is only 196 percent This delta will increase slowly as the 420 call becomes in the money; but the net gamma it is nearly completely offset meaning that the change in the delta will be very slow as the market moves higher The bull call spread will not return quick pro ts The spread is designed to allow time decay to work on the short call option premium through the remaining life of the option In the model you can see this delta effect in the intermediate time

The System Monitoring Plug-in for the Oracle Exadata Storage Server enables you to manage and monitor Exadata Storage Server targets using Oracle Enterprise Manager The plug-in allows you to gather storage configuration and performance information about the Exadata Storage Server components such as cell disks, grid disks, and the Exadata Smart Flash Cache The plug-in also allows you to utilize the notification and alerts infrastructure of Enterprise Manager to propagate alerts originally triggered by the Exadata Storage Servers, made possible by setting thresholds on the Exadata Storage Server metrics within Enterprise Manager Moreover, the

FATTY ACID SYNTHESIS ATP COSTS (FOR C16)

8 acetyl-CoAmito 8 acetyl-CoAcyto 7 acetyl-CoA 7 malonyl-CoA 14NADPH 14NADP Total cost: 16 ATP 7 ATP 42 ATP 65 ATP

5:

Calculating energy costs for the synthesis of a C16 fatty acid from acetyl-CoA is not as simple as you might first think The major complication is that acetyl-CoA is made in the mitochondria, but fatty acid synthesis occurs in the cytosol acetyl-CoA can t cross the mitochondrial membrane Acetyl-CoA gets out of the mitochondria disguised as citrate The acetyl-CoA is condensed with oxaloacetate to give citrate, and the citrate leaves the mitochondria In the cytosol, the citrate is cleaved by an ATP-dependent citrate lyase into acetyl-CoA and oxaloacetate: Citrate ATP CoA acetyl-CoA ADP Pi oxaloacetate

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